Aspirin Research Today is a free monthly online journal that collates and summarizes the latest research about Aspirin, including details on acetylsalicylic acid, baby aspirin, side effects, overdose, allergy.

Drug insight: aspirin resistance--fact or fashion?

Patrono C, Rocca B

University of Rome La Sapienza, Ospedale Sant'Andrea, Via di Grottarossa 1035, 00189 Rome, Italy. cpatrono@unich.it

The term aspirin resistance has been used increasingly in clinical studies. The aim of this Review is to analyze the origin of this term, to discuss the biochemical, functional and clinical correlates of the phenomenon and to offer a conceptual framework to redefine the major determinants of variability between individuals in response to aspirin. Awareness needs to be increased of factors that might interfere with the desired antiplatelet effect of aspirin, particularly in terms of patients' adherence to treatment and avoidable drug interactions with some traditional NSAIDs. Gaining such knowledge could result in improved care of patients and might avoid the requesting of unnecessary platelet function tests of unproven clinical significance.

Published 20 December 2006 in Nat Clin Pract Cardiovasc Med, 4(1): 42-50.
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