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Warfarin vs aspirin for symptomatic intracranial stenosis: subgroup analyses from WASID.

Kasner SE, Lynn MJ, Chimowitz MI, Frankel MR, Howlett-Smith H, Hertzberg VS, Chaturvedi S, Levine SR, Stern BJ, Benesch CG, Jovin TG, Sila CA, Romano JG,

Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA. kasner@mail.med.upenn.edu

The WASID trial showed no advantage of warfarin over aspirin for preventing the primary endpoint of ischemic stroke, brain hemorrhage, or vascular death. In analyses of selected subgroups, there was no definite benefit from warfarin. Warfarin reduced the risk of the primary endpoint among patients with basilar artery stenosis, but there was no reduction in stroke in the basilar artery territory or benefit for vertebral artery stenosis or posterior circulation disease in general.

Published 10 October 2006 in Neurology, 67(7): 1275-8.
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