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Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in growth hormone treated animals.

Prattali RR, Barreiro GC, Caliseo CT, Fugiwara FY, Ueno M, Prada PO, Velloso LA, Saad MJ, Carvalheira JB

Departamento de Clínica Médica, FCM, Universidade Estadual de Campinas (UNICAMP), 13081-970 Campinas, SP, Brazil.

In this study, we demonstrate that pretreatment with aspirin inhibits GH-induced insulin resistance. GH was observed to lead to serine phosphorylation of IRS-1, a phenomenon which was reversed by aspirin in liver, muscle and WAT in parallel with a reduction in JNK activity. In addition, our data show an impairment of insulin activation in the IR/IRS/PI(3)kinase pathway and a reduction in IRS-1 protein levels in rats treated with GH, which was also reversed in the animals pretreated with aspirin. Overall, these results provide new insights into the mechanism of GH-induced insulin resistance.

Published 6 June 2005 in FEBS Lett, 579(14): 3152-8.
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